Bioinformatics Scientist

Job opening ID


Posting title

Bioinformatics Scientist

Roles and responsibilities

Must be a US Citizen
Some travel may be required

Columbus Technologies and Services Inc. is a strategic supplier and business partner to the federal government and its key suppliers.  Through our partnership with the National Institutes of Health, Columbus offers administrative, IT, engineering, scientific, and healthcare professionals the opportunity to work with one of the most prestigious research organizations in the world.  We are currently seeking a Bioinformatics Scientist to work onsite with the National Institutes of Health in Bethesda, MD.

This is a long-term contract position which offers:
 - Competitive salary with comprehensive benefit package
 - Tremendous growth opportunity
 - Opportunity to work at NIH, the world's foremost medical research center
 - Learn more about what Columbus can do for you at

Job Description:
Collaborate with LGCP investigators on ongoing projects and facilitate the completion of computational tasks related to these projects.
Make recommendations to LGCP investigators about the correct computational tools for testing scientific hypotheses and reaching valid conclusions.
Participate in research design with LGCP investigators for determining best practices pertaining to the bioinformatics analysis in new and ongoing projects.
Work with LGCP investigators to improve the computational analysis methods (including handling of large scale datasets, alignment pipelines, new or improved pipelines for data analysis, functional analysis tools and integrative systems biology where applicable) on current projects.
Perform sequencing and alignment of raw data, and interpret new data using larger public access datasets, such as TCGA.
Independently review pertinent literature in the field of genitourinary cancer biology and formulate new scientific questions that can be addressed using computational means or a combination of wetlab and drylab approaches.
Independently identify new tools and resources for analysis of data generated by LGCP.
Perform functional prediction of mutation, copy number, epigenetic, and transcriptome data, and integration of datasets; identifying new tools and resources for reaching biologically meaningful conclusions.
Perform independent bioinformatics research, based on the emergence of new genomics/genetics/epigenetics/proteomics datasets, tools, software and other resources that contribute to the understanding of the mission of the LGCP.
Interpret, analyze, report and publish the results of independent and collaborative research.
Contribute to the production of peer-reviewed research papers, oral presentations and posters, and informal discussion of research results, including the generation of well-designed figures and tables for collaborative and independent research.
Prepare datasets for publication and deposit in controlled-access databases.

Ph. D. in Biological Sciences, Computational Biology or a related discipline, with a minimum of three (3) years of postdoctoral experience.
Proficiency in distributed computing systems (such as SLURM, PBS or LSF).
Demonstrated experience working with DNA and RNA alignment pipelines according to accepted best practices guidelines, such as GATK.
Experience working with large genomic and genetic datasets (including NGS and array) and appropriate analytical tools, including methods for cross-platform comparison.
Programming experience in at least one language.
Comprehensive knowledge of statistical computation.
Demonstrated experience preparing data into figures for publication in peer-reviewed manuscripts.
Experience interpreting dense genomics and genetics data in the context of relevant biological phenotypes.
Strong English communications skills, both oral and written.
Excellent analytical, organizational, record-keeping and time management skills.

Number of positions